Lipase member N

Lipase member N (LIPN) is a protein that in humans is encoded by the LIPN gene. This protein is part of the lipase family, a group of enzymes that play a crucial role in lipid metabolism by catalyzing the hydrolysis of triglycerides into glycerol and free fatty acids.

Function

The LIPN protein is a lipase, an enzyme that breaks down dietary fats into smaller molecules that the body can use. Lipases perform essential roles in the digestion, transport and processing of dietary lipids (e.g., triglycerides, fats, oils) in most, if not all, living organisms.

Clinical significance

Mutations in the LIPN gene have been associated with ichthyosis, a group of skin disorders characterized by dry, scaly skin. In particular, a rare form of ichthyosis known as ichthyosis prematurity syndrome has been linked to mutations in this gene.

See also

• Lipase
• Ichthyosis
• Lipid metabolism

References

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