Linkage analysis
Linkage analysis is a method used in genetics to map genes on chromosomes and to locate the position of genes in relation to other genes. It is based on the observation that genes that are close together on the same chromosome tend to be inherited together.
Pronunciation
- Linkage: /ˈlɪŋkɪdʒ/
- Analysis: /əˈnælɪsɪs/
Etymology
The term "linkage" comes from the English word "link", which means to connect or join. The term "analysis" comes from the Greek word "analusis", which means a breaking up or a loosening.
Related Terms
- Genetic linkage: The tendency of DNA sequences that are close together on a chromosome to be inherited together during the meiosis phase of sexual reproduction.
- Linkage map: A map of the relative positions of genetic loci on a chromosome, determined on the basis of how often the loci are inherited together.
- Linkage disequilibrium: The non-random association of alleles at two or more loci, not necessarily on the same chromosome.
- Recombination: The process by which genetic material is physically mixed during sexual reproduction.
Description
Linkage analysis is a powerful tool used in genetics to help map the location of genes. It is based on the concept of genetic linkage, which refers to the tendency of genes that are close together on a chromosome to be inherited together. This is due to the fact that during meiosis, the process of cell division that produces gametes, chromosomes can exchange genetic material in a process known as recombination. The closer two genes are to each other on a chromosome, the less likely they are to be separated by recombination, and thus the more likely they are to be inherited together.
Linkage analysis can be used to map the location of genes on chromosomes, to identify genes that are associated with specific diseases, and to study the evolutionary history of species. It is a fundamental tool in the field of genetic research and has been instrumental in many significant scientific discoveries.
See Also
External links
- Medical encyclopedia article on Linkage analysis
- Wikipedia's article - Linkage analysis
This WikiMD dictionary article is a stub. You can help make it a full article.
Languages: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
Urdu,
বাংলা,
తెలుగు,
தமிழ்,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
European
español,
Deutsch,
français,
русский,
português do Brasil,
Italian,
polski