Laronidase
Laronidase (pronounced la-RO-ni-dase) is a type of enzyme used in the treatment of Mucopolysaccharidosis I (MPS I), a rare genetic disorder.
Pronunciation
The term 'Laronidase' is pronounced as la-RO-ni-dase.
Etymology
The term 'Laronidase' is derived from the name of the Israeli endocrinologist Zvi Laron, who first described the condition Laron syndrome, and the suffix '-idase', which is used in biochemistry to denote enzymes that catalyze the hydrolysis of certain compounds.
Definition
Laronidase is a recombinant form of the human enzyme alpha-L-iduronidase, which is deficient in individuals with MPS I. It is used as a form of enzyme replacement therapy to help reduce the non-neurological symptoms and complications of MPS I.
Usage
Laronidase is administered through intravenous infusion, usually once a week. The dosage is determined by the patient's body weight.
Related Terms
- Enzyme: A protein that acts as a catalyst in the body to speed up chemical reactions.
- Mucopolysaccharidosis I (MPS I): A rare genetic disorder caused by a deficiency in the enzyme alpha-L-iduronidase.
- Enzyme Replacement Therapy (ERT): A treatment method that involves replacing a missing or deficient enzyme in the body.
- Recombinant DNA technology: A technology used to create Laronidase, which involves combining DNA molecules from different sources into one molecule.
See Also
External links
- Medical encyclopedia article on Laronidase
- Wikipedia's article - Laronidase
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