LRP3
LRP3 or Low-density lipoprotein receptor-related protein 3 is a protein that in humans is encoded by the LRP3 gene. The LRP3 gene is located on chromosome 19 in humans. The protein encoded by this gene is a member of the LDL receptor family, which are cell surface proteins involved in receptor-mediated endocytosis of specific ligands.
Function
LRP3 is a member of the LDL receptor family, which are cell surface proteins involved in receptor-mediated endocytosis of specific ligands. These proteins play a critical role in the control of cholesterol homeostasis. The LRP3 protein is thought to play a role in the cellular uptake of cholesterol and lipids.
Clinical significance
Mutations in the LRP3 gene have been associated with various diseases, including hypercholesterolemia, atherosclerosis, and coronary artery disease. Further research is needed to fully understand the role of LRP3 in these conditions.
See also
- Low-density lipoprotein receptor family
- Hypercholesterolemia
- Atherosclerosis
- Coronary artery disease
References
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Contributors: Prab R. Tumpati, MD
