Allylglycine

Allylglycine is a derivative of the amino acid glycine that has an allyl group replacing one of the hydrogen atoms. It is a convulsant drug that causes seizures by inhibiting the enzyme glutamic acid decarboxylase, thus reducing the production of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).

Chemistry

Allylglycine is a derivative of the amino acid glycine, where one of the hydrogen atoms is replaced by an allyl group. The allyl group consists of a carbon chain with a double bond, which gives the molecule its unique properties.

Pharmacology

Allylglycine acts as a convulsant drug, causing seizures by inhibiting the enzyme glutamic acid decarboxylase. This enzyme is responsible for the production of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter. By reducing the production of GABA, allylglycine disrupts the balance of excitatory and inhibitory signals in the brain, leading to increased neuronal activity and seizures.

Uses

While allylglycine itself is not used in medicine due to its convulsant effects, it is used in research to study the role of GABA in the brain and the mechanisms of seizures. It is also used to induce seizures in laboratory animals for the study of epilepsy and the development of new anticonvulsant drugs.

See also

• Glycine
• Convulsant
• Glutamic acid decarboxylase
• Gamma-aminobutyric acid

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  Allylglycine