JWH-149
Overview
JWH-149 is a synthetic cannabinoid that acts as a potent agonist at the cannabinoid receptors. It is part of the naphthoylindole family of compounds, which are known for their psychoactive effects similar to those of tetrahydrocannabinol (THC), the primary active component of cannabis.
Chemical Structure
JWH-149 is chemically classified as a naphthoylindole, which is characterized by a naphthalene group attached to an indole core. The specific structure of JWH-149 includes a 1-pentyl-3-(1-naphthoyl)indole configuration, which contributes to its high affinity for cannabinoid receptors.
Pharmacology
JWH-149 acts as a full agonist at both the CB1 and CB2 cannabinoid receptors. These receptors are part of the endocannabinoid system, which plays a role in regulating various physiological processes such as mood, appetite, and pain sensation. The activation of these receptors by JWH-149 can lead to effects similar to those produced by natural cannabinoids.
Effects
The effects of JWH-149 are similar to those of other synthetic cannabinoids and can include euphoria, altered perception, and relaxation. However, due to its potency, JWH-149 can also cause adverse effects such as anxiety, paranoia, and tachycardia. The use of synthetic cannabinoids like JWH-149 has been associated with a range of health risks, particularly when used in high doses or in combination with other substances.
Legal Status
The legal status of JWH-149 varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of accepted medical use. The regulation of synthetic cannabinoids is often part of broader efforts to control new psychoactive substances.
Related Compounds
JWH-149 is part of a larger group of synthetic cannabinoids developed by John W. Huffman and his team. Other related compounds include JWH-018, JWH-073, and JWH-250, each with varying affinities and effects on cannabinoid receptors.
See Also
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