JWH-146

Overview

JWH-146 is a synthetic cannabinoid that acts as a potent agonist at the cannabinoid receptors. It is part of the JWH series of compounds, which were developed by Dr. John W. Huffman and his team in the 1990s. These compounds are primarily used in scientific research to study the endocannabinoid system and its effects on the human body.

Chemical Structure

Chemical structure of JWH-146

JWH-146 is classified as a naphthoylindole, which is a type of synthetic cannabinoid. Its chemical structure is characterized by a naphthalene group attached to an indole core. This structure is similar to other compounds in the JWH series, which are known for their high affinity for cannabinoid receptors.

Mechanism of Action

JWH-146 functions as an agonist at the CB1 and CB2 receptors, which are part of the endocannabinoid system. These receptors are involved in a variety of physiological processes, including pain modulation, appetite regulation, and immune response. By binding to these receptors, JWH-146 can mimic the effects of naturally occurring cannabinoids like anandamide and 2-arachidonoylglycerol.

Pharmacological Effects

The activation of cannabinoid receptors by JWH-146 can lead to a range of effects, including analgesia, anti-inflammatory effects, and neuroprotection. However, due to its synthetic nature, the effects of JWH-146 can be more potent and longer-lasting compared to natural cannabinoids. This has made it a compound of interest in the study of cannabinoid pharmacology.

Legal Status

The legal status of JWH-146 varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of medical use. The United States, for example, has placed many synthetic cannabinoids, including those in the JWH series, under Schedule I of the Controlled Substances Act.

Research Applications

JWH-146 is primarily used in scientific research to explore the endocannabinoid system and its role in various physiological and pathological processes. Researchers use it to study the effects of cannabinoid receptor activation and to develop potential therapeutic agents targeting these pathways.

Safety and Toxicity

As with many synthetic cannabinoids, the safety profile of JWH-146 is not well-established. It is known that synthetic cannabinoids can have unpredictable effects and may pose significant health risks. Therefore, JWH-146 is typically handled with caution in research settings.

Related Pages

• Cannabinoid receptor
• Endocannabinoid system
• Synthetic cannabinoids
• JWH series