J-113,397

J-113,397 is a drug used in scientific research, which acts as a potent and selective antagonist for the nociceptin receptor, also known as the ORL1 receptor. It has analgesic, anti-inflammatory and anxiolytic effects, and reverses the memory impairment produced by agonists at this receptor.

Pharmacology

J-113,397 is a potent and selective antagonist for the nociceptin receptor, also known as the ORL1 receptor. This receptor is a G protein-coupled receptor that is closely related to the classical opioid receptors, but has different effects and distribution in the brain. J-113,397 has been shown to block the effects of nociceptin, the endogenous ligand for the ORL1 receptor, in a variety of animal models.

Effects

J-113,397 has analgesic, anti-inflammatory and anxiolytic effects. It has been shown to reverse the memory impairment produced by agonists at the ORL1 receptor. This suggests that the ORL1 receptor may be involved in the regulation of cognitive processes, and that antagonists at this receptor may have therapeutic potential in the treatment of cognitive disorders.

Research

Research into the effects of J-113,397 and other ORL1 receptor antagonists is ongoing. These drugs have potential for the treatment of a variety of conditions, including pain, inflammation, anxiety and cognitive disorders. However, further research is needed to fully understand the role of the ORL1 receptor in these conditions and the potential benefits and risks of drugs that target this receptor.

See also

• Nociceptin receptor
• Opioid receptor
• G protein-coupled receptor

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J-113,397

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  J-113,397 structure

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  J-113,397 synthesis (2007)