Isograft

Isograft is a type of graft that involves the transfer of tissue from one individual to another individual of the same genetic makeup. This is typically done between identical twins or clones. Isografts are unique in that they do not elicit an immune response, and therefore do not require immunosuppressive therapy.

Overview

An isograft is a type of transplant that involves the transfer of cells, tissues, or organs from one individual to another who has an identical genetic makeup. This is typically done between identical twins or clones. Because the genetic makeup of the donor and recipient are identical, the recipient's immune system does not recognize the graft as foreign, and therefore does not mount an immune response against it. This is in contrast to other types of grafts, such as allografts and xenografts, which do elicit an immune response and require the recipient to take immunosuppressive drugs to prevent graft rejection.

Applications

Isografts have a number of medical applications. They are used in transplant surgery to replace damaged or diseased tissues or organs. Because they do not elicit an immune response, they have a high success rate and do not require the recipient to take immunosuppressive drugs. This makes them a preferred choice for transplants when a genetically identical donor is available.

Advantages and Disadvantages

The main advantage of isografts is that they do not elicit an immune response, which means they have a high success rate and do not require the recipient to take immunosuppressive drugs. However, the main disadvantage is that a genetically identical donor is required, which is often not possible. In these cases, other types of grafts, such as allografts or xenografts, may be used instead.

See Also

• Graft (surgery)
• Transplant rejection
• Immunosuppressive drug
• Allograft
• Xenograft

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