Inflammaging

Inflammaging is a term that combines "inflammation" and "aging". It refers to a low-grade, chronic, systemic inflammation in aging, in the absence of infection. This condition is a highly significant risk factor for both morbidity and mortality in the elderly people, as most if not all age-related diseases share an inflammatory pathogenesis.

Causes

The causes of inflammaging are believed to be an accumulation of various factors over time. These include genetic predisposition, lifestyle factors such as diet and exercise, and exposure to environmental toxins.

Symptoms

Inflammaging is often asymptomatic, meaning it does not present any noticeable symptoms. However, it can be detected through blood tests that measure levels of inflammatory markers such as C-reactive protein (CRP).

Treatment

There is currently no specific treatment for inflammaging. However, lifestyle modifications such as a healthy diet, regular exercise, and avoiding exposure to environmental toxins can help reduce inflammation and slow the aging process.

See Also

• Aging
• Inflammation
• Chronic disease
• C-reactive protein

References

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  Schematic representation of inflammaging
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  Three models of NLRP3 inflammasome activation
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  TNF-mediated death and survival pathways
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  Crystal structure of TNF-alpha
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  Inflammaging
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  SARS-CoV-2 virus