ID4
ID4 or Inhibitor of DNA binding 4 is a protein that in humans is encoded by the ID4 gene. It is a member of the inhibitor of DNA binding family, members of which are transcriptional regulators that contain a helix-loop-helix (HLH) domain but not a basic domain.
Function
Members of the ID family inhibit the functions of basic helix-loop-helix transcription factors in a dominant-negative manner by suppressing their heterodimerization partners through the HLH domains. This protein may play a role in negatively regulating cell differentiation. A mutation in this gene has been associated with a specific type of adenocarcinoma.
Clinical significance
ID4 has been implicated in various types of cancer, including breast cancer, ovarian cancer, and glioblastoma. It is thought to act as a tumor suppressor in some contexts, but may promote cancer growth in others. The exact mechanisms by which ID4 influences cancer development and progression are still being investigated.
See also
References
External links
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Contributors: Prab R. Tumpati, MD
