Hypocretin (orexin) receptor 1

From Food & Medicine Encyclopedia

Hypocretin (orexin) receptor 1 is a protein that in humans is encoded by the HCRTR1 gene. It is also known as OX1R or OX1 and is one of the two receptors that bind to the neuropeptides hypocretin (also known as orexin).

Function[edit]

Hypocretin receptor 1 is a G protein-coupled receptor that is involved in the regulation of feeding behavior. The activity of this receptor is mediated by G proteins that activate a phosphatidylinositol-calcium second messenger system.

Clinical significance[edit]

Mutations in the HCRTR1 gene have been associated with narcolepsy, a neurological condition characterized by excessive daytime sleepiness, cataplexy, and rapid eye movement (REM) sleep abnormalities.

Ligands[edit]

Several ligands are known to bind to the hypocretin receptor 1, including the hypocretin peptides hypocretin-1 and hypocretin-2.

See also[edit]

References[edit]

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