Hydroxycarbamide
Hydroxycarbamide (Hydroxyurea)[edit]
Hydroxycarbamide, also known as hydroxyurea, is a medication widely used in the treatment of various diseases, including sickle-cell disease, essential thrombocythemia, chronic myelogenous leukemia, and cervical cancer.
Medical Uses[edit]
Hydroxycarbamide is employed in the management of:
- Sickle-cell disease: Increases fetal hemoglobin levels and reduces the frequency of pain attacks.
- Essential thrombocythemia and chronic myelogenous leukemia: Helps in controlling the overproduction of blood cells.
- Cervical cancer: Used as a part of chemotherapeutic regimens.
Mechanism of Action[edit]
Hydroxycarbamide works by inhibiting ribonucleotide reductase, an enzyme crucial for DNA synthesis. This action helps in reducing the proliferation of rapidly dividing cells.
History[edit]
Hydroxycarbamide was first approved for medical use in the United States in 1967. It represented a significant advancement in the treatment of certain blood disorders and cancers.
Availability and Essential Medicine Status[edit]
It is included in the World Health Organization's List of Essential Medicines, highlighting its importance in a health system. Hydroxycarbamide is available as a generic medication, making it accessible and affordable.
External Links[edit]
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