Hexafluoroacetone
Hexafluoroacetone (HFA) is a chemical compound with the formula (CF₃)₂CO. It is a colorless, highly reactive, and volatile liquid that is used in various industrial and chemical applications.
Chemical Properties
Hexafluoroacetone is characterized by its high reactivity due to the presence of six fluorine atoms attached to the central carbonyl group. This makes it a strong electrophile and a useful reagent in organic synthesis. The compound has a boiling point of 15.5°C and is typically stored under refrigeration to prevent decomposition.
Synthesis
Hexafluoroacetone can be synthesized through the fluorination of acetone using elemental fluorine or other fluorinating agents. The process involves the replacement of hydrogen atoms in acetone with fluorine atoms, resulting in the formation of hexafluoroacetone.
Applications
Hexafluoroacetone is used in various applications, including:
- As a precursor in the synthesis of fluorinated organic compounds.
- In the production of fluoropolymers and other high-performance materials.
- As a reagent in organic chemistry for the introduction of fluorine atoms into molecules.
Safety and Handling
Hexafluoroacetone is highly toxic and poses significant health risks if inhaled, ingested, or comes into contact with skin. Proper safety measures, including the use of personal protective equipment (PPE) and adequate ventilation, are essential when handling this compound. It is also a potent lachrymator, causing severe irritation to the eyes and respiratory system.
Related Compounds
See Also
References
External Links
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Contributors: Prab R. Tumpati, MD