Hesperadin
Hesperadin
Hesperadin (pronounced hes-per-a-din) is a small molecule inhibitor of the human Aurora B kinase, a protein that plays a significant role in the proper segregation of chromosomes during cell division.
Etymology
The term "Hesperadin" is derived from the Greek word "Hespera", meaning "evening", and the suffix "-din", which is commonly used in the nomenclature of pharmaceutical drugs. The name is likely a reference to the drug's ability to "bring about the end" of uncontrolled cell division, much like the evening brings about the end of the day.
Function
Aurora kinases are a family of serine/threonine kinases that play a crucial role in cell division. They are involved in the regulation of the mitotic spindle, a structure that separates chromosomes during mitosis. Hesperadin inhibits the activity of Aurora B kinase, thereby preventing the uncontrolled division of cells that is characteristic of many types of cancer.
Related Terms
Clinical Use
Hesperadin has been studied for its potential use in the treatment of various types of cancer, including breast cancer, colorectal cancer, and leukemia. It is not currently approved for use in humans, but preclinical studies have shown promising results.
Side Effects
As with any drug, Hesperadin may cause side effects. These can include nausea, vomiting, and fatigue. More serious side effects can include low blood cell counts, which can lead to an increased risk of infection.
See Also
External links
- Medical encyclopedia article on Hesperadin
- Wikipedia's article - Hesperadin
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