Vitamin K deficiency bleeding

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Obesity, Sleep & Internal medicine
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Vitamin K deficiency bleeding
Chemical structure of Phylloquinone, a form of Vitamin K
Synonyms	Hemorrhagic disease of the newborn
Pronounce	N/A
Specialty	N/A
Symptoms	Bleeding, bruising, hematoma, intracranial hemorrhage
Complications	Severe bleeding, anemia, shock
Onset	Within the first week of life (early), 2-12 weeks (classic), or after 12 weeks (late)
Duration	Varies depending on treatment
Types	N/A
Causes	Vitamin K deficiency
Risks	Breastfeeding, maternal medication, liver disease
Diagnosis	Prothrombin time test, partial thromboplastin time test
Differential diagnosis	Hemophilia, thrombocytopenia, liver disease
Prevention	Vitamin K prophylaxis at birth
Treatment	Vitamin K supplementation
Medication	Vitamin K1 (phytonadione)
Prognosis	N/A
Frequency	Rare in developed countries with prophylaxis
Deaths	N/A

Vitamin K deficiency bleeding (VKDB) is a coagulopathy that results from inadequate Vitamin K levels in the body. It is a serious condition that can lead to significant health complications, including hemorrhage and even death if not promptly treated.

Causes

VKDB is primarily caused by insufficient intake or absorption of Vitamin K, which is essential for the synthesis of certain clotting factors in the liver. This deficiency can occur due to several reasons:

• Newborns, especially premature ones, are at a higher risk as they have low Vitamin K levels at birth and the vitamin does not cross the placenta well.
• Certain medications, such as antibiotics, anticoagulants, and anticonvulsants, can interfere with Vitamin K absorption or function.
• Certain health conditions, such as cystic fibrosis, celiac disease, or liver disease, can affect the body's ability to absorb Vitamin K.

Symptoms

The primary symptom of VKDB is bleeding, which can occur in various parts of the body. This includes:

• Gastrointestinal bleeding
• Nosebleeds
• Bleeding gums
• Hematuria (blood in urine)
• Menorrhagia (heavy menstrual bleeding)

In severe cases, VKDB can lead to intracranial hemorrhage, a life-threatening condition where bleeding occurs inside the skull.

Treatment

Treatment for VKDB involves the administration of Vitamin K, usually through an injection. In severe cases, blood transfusion may be necessary.

Prevention

Prevention of VKDB is primarily through ensuring adequate intake of Vitamin K. This is particularly important for newborns, who are typically given a Vitamin K injection shortly after birth to prevent VKDB.

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