Hematoxylin body

Hematoxylin body is a term used in pathology to describe a specific type of cellular change. It is often associated with certain autoimmune diseases, such as lupus.

Overview

Hematoxylin bodies are named for their staining characteristics. They are basophilic, meaning they stain blue or purple with hematoxylin, a common dye used in histology. These bodies are actually fragments of cells that have been damaged or destroyed. They are often found in the kidney, skin, and other tissues in people with lupus and other autoimmune diseases.

Pathology

In the context of pathology, hematoxylin bodies are a type of apoptotic body. Apoptosis is a process of programmed cell death, and apoptotic bodies are the fragments of cells that result from this process. Hematoxylin bodies are a specific type of apoptotic body that stain with hematoxylin.

Clinical significance

The presence of hematoxylin bodies in a tissue sample can be a clue to the diagnosis of certain autoimmune diseases. For example, they are often found in the kidneys of people with lupus nephritis, a serious complication of lupus that affects the kidneys. They can also be found in the skin and other tissues in people with lupus and other autoimmune diseases.

See also

• Systemic lupus erythematosus
• Lupus nephritis
• Apoptosis
• Histology
• Pathology

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