Hemagglutination
Hemagglutination
Hemagglutination (pronunciation: hee-muh-gloo-tuh-ney-shuhn) is a process that causes red blood cells to clump together. The term is derived from the Greek words 'haima' meaning 'blood' and 'gloutos' meaning 'glue'.
Overview
Hemagglutination is a specific agglutination process that involves the clumping of red blood cells. It is commonly used in laboratory tests to identify blood types and to detect certain viruses, such as the Influenza virus, which have the ability to cause hemagglutination.
Mechanism
The process of hemagglutination is initiated by Hemagglutinins, a type of protein found on the surface of certain viruses and bacteria. These proteins bind to specific receptors on the surface of red blood cells, causing them to clump together. This clumping can be observed under a microscope and is used as an indicator of the presence of the virus or bacteria.
Hemagglutination in Medical Testing
Hemagglutination is used in a variety of medical tests. The Hemagglutination inhibition test is used to detect antibodies against viruses in a patient's serum. The Direct Coombs test and the Indirect Coombs test are used to detect antibodies that can cause hemagglutination in certain conditions, such as hemolytic anemia and Rh incompatibility in pregnancy.
Related Terms
- Hemagglutinin: A type of protein that causes hemagglutination.
- Agglutination: The clumping together of particles, often used in reference to cells or bacteria.
- Hemolysis: The breakdown of red blood cells.
- Serology: The scientific study of serum and other bodily fluids.
External links
- Medical encyclopedia article on Hemagglutination
- Wikipedia's article - Hemagglutination
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