Halicephalobus gingivalis
Halicephalobus gingivalis is a free-living nematode that is commonly found in the environment, particularly in soil and manure. It is a rare cause of disease in humans and animals, most notably horses, where it can cause a fatal neurological condition known as Halicephalobus meningitis.
Taxonomy
Halicephalobus gingivalis belongs to the phylum Nematoda, which includes a diverse group of organisms commonly referred to as roundworms. It is part of the family Rhabditidae, which is characterized by free-living nematodes that are often associated with decaying organic matter.
Life Cycle
The life cycle of Halicephalobus gingivalis is not fully understood. As a free-living nematode, it is capable of reproducing both sexually and asexually. The nematode is thought to be primarily saprophytic, feeding on decaying organic matter, but can become parasitic under certain conditions.
Pathogenesis
Halicephalobus gingivalis is a rare cause of disease in humans and animals. In horses, it can cause a fatal neurological condition known as Halicephalobus meningitis. The nematode is thought to enter the body through wounds or possibly through the ingestion of contaminated soil or water. Once inside the body, it can migrate to various tissues, including the brain, where it can cause severe inflammation and damage.
Diagnosis and Treatment
Diagnosis of Halicephalobus gingivalis infection is challenging due to the rarity of the disease and the nonspecific nature of the symptoms. Treatment is also difficult, as the nematode is resistant to many common anthelmintic drugs. Surgical removal of the affected tissue may be necessary in some cases.
Epidemiology
Halicephalobus gingivalis is found worldwide, but cases of disease are rare. Most reported cases have occurred in horses, but infections in humans and other animals have also been reported.
See Also
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Contributors: Prab R. Tumpati, MD