H1 receptor
H1 Receptor
The H1 receptor (pronounced as "H one receptor") is a subtype of the Histamine receptor, which is a G protein-coupled receptor (GPCR) that binds histamine as its primary ligand.
Etymology
The term "H1 receptor" is derived from the primary ligand it binds to, histamine, and it being the first subtype of histamine receptors to be discovered.
Function
The H1 receptor plays a crucial role in allergic reactions. When histamine binds to the H1 receptor, it results in symptoms such as vasodilation, bronchoconstriction, smooth muscle activation, and separation of endothelial cells (which can cause hives).
Related Terms
- Histamine: A compound that is released by cells in response to injury and in allergic and inflammatory reactions, causing contraction of smooth muscle and dilation of capillaries.
- G protein-coupled receptor (GPCR): A large protein family of receptors that detect molecules outside the cell and activate internal signal transduction pathways.
- Ligand: A molecule that binds to another (usually larger) molecule.
- Vasodilation: The dilatation of blood vessels, which decreases blood pressure.
- Bronchoconstriction: The constriction of the airways in the lungs due to the tightening of surrounding smooth muscle.
- Endothelial cells: Cells that line the interior surface of blood vessels and lymphatic vessels.
- Hives: A kind of skin rash notable for pale red, raised, itchy bumps.
External links
- Medical encyclopedia article on H1 receptor
- Wikipedia's article - H1 receptor
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