Gorlin sign

Gorlin sign

A demonstration of Gorlin sign in a patient with Ehlers-Danlos syndrome

The Gorlin sign is a clinical sign characterized by the ability to touch the tip of the nose with the tongue. This sign is often associated with certain connective tissue disorders, most notably Ehlers-Danlos syndrome (EDS).

Clinical significance

The Gorlin sign is considered a marker of connective tissue laxity. It is observed in approximately 50% of patients with Ehlers-Danlos syndrome, a group of disorders that affect the connective tissues supporting the skin, bones, blood vessels, and many other organs and tissues. The presence of the Gorlin sign can aid in the clinical diagnosis of EDS, although it is not exclusive to this condition and can be seen in a small percentage of the general population.

Associated conditions

• Ehlers-Danlos syndrome: A group of genetic disorders that affect the connective tissues, characterized by hypermobile joints, skin hyperextensibility, and tissue fragility.
• Marfan syndrome: Another connective tissue disorder that can occasionally present with the Gorlin sign, though it is less common than in EDS.

Examination

To test for the Gorlin sign, a clinician asks the patient to attempt to touch the tip of their nose with their tongue. The ability to do so is considered a positive Gorlin sign. It is important to note that while the sign can be indicative of connective tissue disorders, it is not diagnostic on its own and should be considered alongside other clinical findings.

Related pages

• Ehlers-Danlos syndrome
• Connective tissue disorder
• Marfan syndrome