Gonadotropin surge-attenuating factor

Gonadotropin surge-attenuating factor (GnSAF) is a non-steroidal ovarian substance that modulates the bioactivity of gonadotropin-releasing hormone (GnRH). It is believed to play a significant role in the regulation of the female reproductive cycle.

Function

GnSAF is produced by the ovary in response to stimulation by follicle-stimulating hormone (FSH). It acts on the pituitary gland to attenuate the preovulatory luteinizing hormone (LH) surge. This modulation of LH surge is crucial for the timing of ovulation and the subsequent establishment of pregnancy.

Biochemical Characteristics

GnSAF is a non-steroidal protein with a molecular weight of approximately 30,000 Daltons. It is heat-stable and resistant to enzymatic digestion. Its exact structure and mechanism of action remain unknown.

Clinical Significance

Abnormalities in GnSAF production or action may contribute to reproductive disorders such as polycystic ovary syndrome (PCOS) and premature ovarian failure (POF). Further research into GnSAF could lead to new treatments for these and other reproductive disorders.

See Also

• Gonadotropin-releasing hormone
• Follicle-stimulating hormone
• Luteinizing hormone
• Polycystic ovary syndrome
• Premature ovarian failure

References

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Gonadotropin surge-attenuating factor

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  Effects of GnSAF on early and late follicular phase