Glucose clamp technique
Glucose clamp technique
The Glucose clamp technique (pronunciation: /ˈɡluːkoʊs klæmp tɛkˈniːk/) is a method used in medical research to measure insulin sensitivity and beta cell function. The technique was first described by DeFronzo et al. in 1979.
Etymology
The term "clamp" in the glucose clamp technique refers to the process of "clamping" or maintaining the blood glucose concentration at a constant level. The word "glucose" is derived from the Greek word "glykys," meaning sweet, and the word "clamp" is derived from the Old English "clamm," meaning bond or fetter.
Procedure
The glucose clamp technique involves the infusion of glucose and insulin into a subject's bloodstream. The glucose infusion rate (GIR) is adjusted based on frequent measurements of blood glucose levels to maintain a constant desired blood glucose concentration. This allows researchers to measure the body's sensitivity to insulin and the function of the beta cells in the pancreas.
Types of Glucose Clamp Techniques
There are two main types of glucose clamp techniques: the hyperglycemic clamp and the euglycemic clamp. The hyperglycemic clamp is used to assess beta cell function, while the euglycemic clamp is used to measure insulin sensitivity.
Related Terms
- Hyperglycemic clamp
- Euglycemic clamp
- Insulin sensitivity
- Beta cell function
- Glucose infusion rate (GIR)
See Also
External links
- Medical encyclopedia article on Glucose clamp technique
- Wikipedia's article - Glucose clamp technique
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