Gamma delta T cell

Gamma delta T cells are a small subset of T cells that possess a distinct T cell receptor (TCR) on their surface. Most T cells are alpha-beta (αβ) T cells with TCR composed of an alpha (α) chain and a beta (β) chain. Unlike αβ T cells, γδ T cells are able to recognize non-peptidic antigens without the need for antigen presenting cells.

Etymology

The name "Gamma delta T cells" comes from the type of T cell receptor (TCR) they express on their cell surface. This TCR is made up of one gamma (γ) chain and one delta (δ) chain, which is different from the alpha (α) and beta (β) chain found on most T cells.

Function

Gamma delta T cells are primarily found in the gut mucosa, where they are believed to contribute to immune responses. They are particularly effective at fighting certain types of infections, including those caused by Mycobacteria and Listeria, and may also play a role in autoimmune diseases.

Related Terms

• T cell
• T cell receptor
• Antigen
• Mycobacteria
• Listeria
• Autoimmune disease

See Also

• Alpha beta T cell
• Immune system
• Infection

References

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  Mouse C57BL6 Vgamma locus