Gain-of-function research

Gain-of-function research (pronunciation: /ɡeɪn ɒv ˈfʌŋkʃən rɪˈsɜːrtʃ/) is a term used in molecular biology to refer to the investigation of the increased potency or altered functionality of pathogens. This type of research is often conducted to understand the potential risks of disease outbreaks and to develop effective vaccines and therapies.

Etymology

The term "gain-of-function" is derived from the concept that the research involves the enhancement or acquisition of new functions in a biological entity, such as a virus or bacteria. The term "research" is from the Old French recherche, meaning "to seek out, search closely".

Related Terms

Molecular biology: The branch of biology that deals with the structure and function of the macromolecules essential to life.
Pathogens: Microorganisms that can cause disease.
Disease: A particular abnormal condition that negatively affects the structure or function of all or part of an organism.
Vaccines: A biological preparation that provides active acquired immunity to a particular infectious disease.
Therapies: Treatment intended to relieve or heal a disorder.
Virus: A small infectious agent that replicates only inside the living cells of an organism.
Bacteria: A type of biological cell, they constitute a large domain of prokaryotic microorganisms.