GDF3

From WikiMD's WELLNESSPEDIA

GDF3 (Growth Differentiation Factor 3) is a protein that in humans is encoded by the GDF3 gene. It is a member of the TGF-beta superfamily of growth and differentiation factors.

Function[edit]

GDF3 is a secreted ligand of the TGF-beta (Transforming Growth Factor-beta) family, which has important roles in the formation of the embryo and in adult tissue homeostasis. It is expressed in various tissues, with high levels in the placenta and lower levels in the kidney and pancreas.

Clinical significance[edit]

Mutations in the GDF3 gene have been associated with various diseases, including cancer, diabetes, and obesity. It has also been implicated in the development of congenital heart defects and eye diseases.

Research[edit]

Research into GDF3 has focused on its role in stem cell differentiation and regenerative medicine. It has been found to be a key regulator of pluripotency in embryonic stem cells.

See also[edit]

References[edit]


External links[edit]

Stub icon

This medical article is a stub. You can help WikiMD by expanding the page.


Medical Disclaimer: WikiMD is for informational purposes only and is not a substitute for professional medical advice. Content may be inaccurate or outdated and should not be used for diagnosis or treatment. Always consult your healthcare provider for medical decisions. Verify information with trusted sources such as CDC.gov and NIH.gov. By using this site, you agree that WikiMD is not liable for any outcomes related to its content. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.

Retrieved from "https://wikimd.org/index.php?title=GDF3&oldid=6507520"