G1 Therapeutics
G1 Therapeutics
G1 Therapeutics, Inc. is a clinical-stage biopharmaceutical company focused on the discovery, development, and delivery of next-generation therapies that improve the lives of those affected by cancer. The company is headquartered in Research Triangle Park, North Carolina, and is known for its innovative approach to cancer treatment.
History
G1 Therapeutics was founded in 2008 as a spin-off from the University of North Carolina at Chapel Hill. The company was established to commercialize discoveries made in the laboratory of Dr. Norman Sharpless, who later became the director of the National Cancer Institute.
Research and Development
G1 Therapeutics is primarily focused on developing small molecule therapies that target the cell cycle to treat cancer. The company's lead product candidates are designed to protect bone marrow from damage caused by chemotherapy and to enhance the efficacy of cancer treatments.
Trilaciclib
Trilaciclib is a first-in-class therapy designed to preserve bone marrow and immune system function during chemotherapy. It is a CDK4/6 inhibitor that is administered intravenously prior to chemotherapy to protect hematopoietic stem cells and immune cells.
Rintodestrant
Rintodestrant is an oral selective estrogen receptor degrader (SERD) being developed for the treatment of hormone receptor-positive breast cancer. It is designed to degrade the estrogen receptor and inhibit the growth of cancer cells.
Clinical Trials
G1 Therapeutics has conducted several clinical trials to evaluate the safety and efficacy of its product candidates. These trials are conducted in collaboration with leading cancer research centers and involve patients with various types of cancer.
Partnerships and Collaborations
The company has established partnerships with several pharmaceutical companies and research institutions to advance its drug development programs. These collaborations are aimed at accelerating the clinical development and commercialization of G1 Therapeutics' therapies.
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Contributors: Prab R. Tumpati, MD
