Furafylline
Furafylline is a potent inhibitor of the enzyme cytochrome P450 1A2, which is involved in the metabolism of various xenobiotics in the body. It is a derivative of theophylline, a methylxanthine drug used in therapy for respiratory diseases such as chronic obstructive pulmonary disease (COPD) and asthma.
Pharmacology
Furafylline has been extensively studied for its ability to inhibit cytochrome P450 1A2. This enzyme is responsible for the metabolism of a variety of substances, including many drugs and environmental toxins. By inhibiting this enzyme, furafylline can affect the clearance of these substances from the body, potentially altering their effects.
Clinical Use
While furafylline itself is not used clinically, it has been used in research to study drug metabolism and interactions. Its potent inhibition of cytochrome P450 1A2 makes it a useful tool for understanding the role of this enzyme in drug clearance and response.
Safety and Toxicity
As with any drug, furafylline has the potential for adverse effects. However, because it is not used clinically, these effects are primarily of concern in the context of research studies. Potential risks include those associated with the inhibition of cytochrome P450 1A2, such as altered drug effects and toxicity.
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Contributors: Prab R. Tumpati, MD
