Forodesine
Forodesine
Forodesine (pronunciation: fo-ro-des-ine) is a transition state analog inhibitor of the enzyme purine nucleoside phosphorylase (PNP). It is primarily used in the treatment of cutaneous T-cell lymphoma (CTCL) and other lymphoproliferative disorders.
Etymology
The term 'Forodesine' is derived from the chemical name of the drug, which is 2-amino-9-2-(phosphonomethoxy)ethyl-1H-purin-6(9H)-one. The name is a combination of the words 'phosphono', 'methoxy', 'ethyl', and 'purin', which describe the chemical structure of the drug.
Usage
Forodesine is used in the treatment of cutaneous T-cell lymphoma (CTCL), a type of non-Hodgkin lymphoma that primarily affects the skin. It is also used in the treatment of other lymphoproliferative disorders, which are conditions characterized by the excessive production of lymphocytes.
Mechanism of Action
Forodesine works by inhibiting the enzyme purine nucleoside phosphorylase (PNP). This enzyme is involved in the breakdown of purine nucleosides, which are essential components of DNA and RNA. By inhibiting PNP, forodesine disrupts the metabolism of these nucleosides, leading to the accumulation of toxic levels of deoxyguanosine triphosphate (dGTP) in lymphocytes. This, in turn, leads to the death of these cells, thereby reducing the symptoms of lymphoproliferative disorders.
Related Terms
- Transition state analog
- Purine nucleoside phosphorylase
- Cutaneous T-cell lymphoma
- Non-Hodgkin lymphoma
- Lymphoproliferative disorders
External links
- Medical encyclopedia article on Forodesine
- Wikipedia's article - Forodesine
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