Fluralaner

An encyclopedia article about Fluralaner, an antiparasitic drug used in veterinary medicine.

Fluralaner

Chemical structure of Fluralaner

Fluralaner is a systemic insecticide and acaricide used in veterinary medicine to treat and prevent flea and tick infestations in animals. It is a member of the isoxazoline class of compounds and is known for its efficacy and long-lasting effects.

Mechanism of Action

Fluralaner works by inhibiting the gamma-aminobutyric acid (GABA)-gated chloride channels in the nervous system of arthropods. This inhibition leads to uncontrolled neuronal activity, resulting in the death of the parasites. The selectivity of fluralaner for insect and acarid GABA receptors over mammalian receptors contributes to its safety profile in treated animals.

Pharmacokinetics

After administration, fluralaner is absorbed into the bloodstream and distributed throughout the body. It is known for its long half-life, which allows for extended protection against parasites. The drug is primarily excreted unchanged in the feces, with a smaller portion being metabolized in the liver.

Uses in Veterinary Medicine

Fluralaner is commonly used in the form of oral tablets or topical solutions for dogs and cats. It provides protection against a variety of ectoparasites, including:

• Fleas (Ctenocephalides felis)
• Ticks (Ixodes scapularis, Rhipicephalus sanguineus, Dermacentor variabilis)

The drug is often marketed under brand names such as Bravecto, which is available in different formulations to suit the needs of different animal species and sizes.

Safety and Side Effects

Fluralaner is generally well-tolerated in animals. Common side effects may include mild gastrointestinal upset, such as vomiting or diarrhea. In rare cases, neurological signs such as tremors or ataxia may occur. It is important to follow the dosing instructions provided by a veterinarian to minimize the risk of adverse effects.

Environmental Impact

As with many veterinary pharmaceuticals, there is concern about the environmental impact of fluralaner, particularly its potential effects on non-target species. Proper disposal of unused medication and packaging is recommended to reduce environmental contamination.

Related pages

• Isoxazoline
• Acaricide
• Flea treatment
• Tick control