Fixed-dose procedure
Fixed-dose procedure
The Fixed-dose procedure (pronunciation: /ˈfɪkst doʊs prəˈsiːdʒər/) is a method used in toxicology to estimate the lethal dose of a substance in animals. The term originates from the English words "fixed" (unchanging) and "dose" (a specific quantity of a medicine), and "procedure" (a series of actions conducted in a certain order).
Definition
The Fixed-dose procedure is a sequential testing procedure that involves administering a substance at a fixed dose to a group of animals and observing them for a set period of time. The aim is to determine the dose that causes mortality or severe toxicity without causing unnecessary suffering to the animals.
Procedure
The procedure begins with a single dose of the substance being administered to a small group of animals. If no adverse effects are observed, the procedure is repeated with a higher dose. This continues until the lethal dose is identified or until a maximum dose is reached. The Fixed-dose procedure is designed to minimize animal suffering while still providing reliable data on the toxicity of the substance.
Related Terms
- Acute toxicity: The harmful effects of a substance that result either from a single exposure or from multiple exposures in a short period of time.
- Lethal dose: The amount of a substance that is sufficient to cause death in an organism.
- Toxicology: The study of the adverse effects of chemicals on living organisms.
See Also
External links
- Medical encyclopedia article on Fixed-dose procedure
- Wikipedia's article - Fixed-dose procedure
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