Factor vii deficiency
Factor VII Deficiency
Factor VII deficiency (pronounced: fak-tor seven de-fi-ciency) is a rare genetic disorder that is characterized by the lack of Factor VII, a protein that plays a crucial role in the process of blood clotting.
Etymology
The term "Factor VII deficiency" is derived from the name of the protein that is deficient in individuals with this condition. The term "deficiency" comes from the Latin word "deficientia", meaning "a lack or shortage".
Definition
Factor VII deficiency is a bleeding disorder that is caused by a lack of Factor VII, a protein that is necessary for blood to clot properly. This condition is inherited in an autosomal recessive manner, meaning that an individual must inherit two copies of the defective gene, one from each parent, in order to develop the disorder.
Symptoms
The symptoms of Factor VII deficiency can vary greatly from person to person. Some individuals may experience severe bleeding episodes, while others may have only mild bleeding or no symptoms at all. Common symptoms include nosebleeds, bruising, gum bleeding, and prolonged bleeding after surgery or injury.
Diagnosis
Diagnosis of Factor VII deficiency is typically made through a series of blood tests that measure the amount of Factor VII in the blood. These tests may include a prothrombin time (PT) test and a Factor VII activity test.
Treatment
Treatment for Factor VII deficiency typically involves replacing the missing Factor VII through infusions of recombinant Factor VIIa, a man-made version of Factor VII. Other treatments may include antifibrinolytic drugs to help prevent bleeding and blood transfusions in severe cases.
Related Terms
- Hemophilia: A group of bleeding disorders in which it takes a long time for the blood to clot.
- Coagulation: The process by which blood changes from a liquid to a gel, forming a blood clot.
- Prothrombin: A protein in the blood that plays a key role in the clotting process.
External links
- Medical encyclopedia article on Factor vii deficiency
- Wikipedia's article - Factor vii deficiency
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