FOXO3

FOXO3 is a gene that encodes the protein FoxO3, a member of the forkhead class of DNA-binding proteins. These proteins are critical regulators of transcription and play important roles in cellular physiological processes. The FOXO3 gene is located on the long (q) arm of chromosome 6 at position 21.

Function

The FOXO3 gene provides instructions for making a member of a family of proteins called forkhead box (FOX) proteins. FOX proteins play important roles in regulating the expression of genes involved in cell growth, proliferation, differentiation, and longevity. Among its associated pathways are Akt Signaling and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and sequence-specific DNA binding.

Clinical significance

Variants of the FOXO3 gene are associated with a significantly increased risk of certain diseases and conditions, including prostate cancer, endometrial cancer, and longevity. The gene has been shown to be a key factor in promoting the survival of cardiac and skeletal muscle cells, and its dysregulation has been implicated in the pathogenesis of diabetes and cancer.

See also

• Forkhead box protein O3
• FOXO1
• FOXO4
• FOXO6

External links

• FOXO3 at the National Center for Biotechnology Information

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