FCRL5

Fc receptor-like protein 5 (FCRL5) is a protein that in humans is encoded by the FCRL5 gene. This gene is part of the Fc receptor-like family, which is involved in the regulation of the immune system.

Function

FCRL5 is a member of the immunoglobulin superfamily and is primarily expressed on B cells. It plays a role in the modulation of B cell receptor signaling and may be involved in the regulation of immune response. FCRL5 has been implicated in various autoimmune diseases and cancers, where it may influence the behavior of malignant B cells.

Structure

The FCRL5 protein contains several immunoglobulin-like domains, which are characteristic of the Fc receptor family. These domains are important for the protein's ability to bind to antigens and other molecules involved in immune signaling.

Clinical significance

Alterations in the expression of FCRL5 have been associated with chronic lymphocytic leukemia and other B cell malignancies. Research suggests that FCRL5 may serve as a potential biomarker for certain hematological disorders.

Research

Studies are ongoing to better understand the role of FCRL5 in immune regulation and its potential as a target for therapeutic intervention in autoimmune diseases and cancer.

See also

• Fc receptor
• B cell
• Immune system

External links

• FCRL5 gene information at NCBI
• FCRL5 protein information at UniProt