Event-related potential

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Event-related potential

Diagram of ERP components

An event-related potential (ERP) is a measured brain response that is the direct result of a specific sensory, cognitive, or motor event. More specifically, ERPs are very small voltages generated in the brain structures in response to specific events or stimuli. They are measured using electroencephalography (EEG).

Components of ERPs

ERPs are characterized by distinct components, which are labeled according to their polarity (positive or negative) and their latency (the time after the stimulus at which they occur). Some of the well-known ERP components include:

  • P300: A positive deflection in voltage with a latency of roughly 300 milliseconds, often associated with the process of decision making.
  • N400: A negative component that peaks around 400 milliseconds, typically associated with the processing of meaning in language.
  • N100: A negative deflection occurring approximately 100 milliseconds after stimulus onset, often related to the initial sensory processing of a stimulus.
  • P600: A positive component that occurs around 600 milliseconds, often linked to syntactic processing in language.

Measurement and Analysis

ERPs are extracted from the EEG by averaging the EEG signals time-locked to the onset of the stimulus. This averaging process enhances the signal-to-noise ratio, allowing researchers to observe the brain's response to specific events. The analysis of ERPs involves examining the amplitude and latency of the components, which can provide insights into the timing and nature of cognitive processes.

Applications

ERPs are used in a variety of research fields, including:

  • Cognitive neuroscience: To study the timing of cognitive processes such as attention, perception, and memory.
  • Clinical research: To investigate abnormalities in brain function in conditions such as schizophrenia, Alzheimer's disease, and autism spectrum disorder.
  • Psycholinguistics: To explore language processing and comprehension.

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Contributors: Prab R. Tumpati, MD