Estradiol valerate/testosterone enanthate

Estradiol valerate/testosterone enanthate (EV/TE), also sold under the brand names Primodian Depot and Ditate among others, is an injectable combination medication of estradiol valerate (EV), an estrogen, and testosterone enanthate (TE), an androgen/anabolic steroid. This medication is primarily used in menopausal hormone therapy for women. Additionally, it is also used to suppress lactation in postpartum women under the brand name Deladumone.

Etymology

The term "estradiol" is derived from estra-, which is a contraction of the Greek οἶστρος (oistros, literally meaning "gadfly" but figuratively sexual passion or desire), -diol, a chemical term and suffix indicating that this form of steroid and sex hormone is a type of alcohol bearing two hydroxyl groups. The "valerate" is derived from valeric acid, which in turn is named after the plant genus Valeriana due to the presence of valeric acid in the roots of plants belonging to this genus. The term "testosterone" is derived from testis (the organ that primarily produces testosterone) and sterol (indicating a steroid) and the suffix -one (indicating a ketone, specifically a ketosteroid).

Usage

The primary use of EV/TE is in menopausal hormone therapy for women. During menopause, the body's natural production of hormones such as estrogen decreases. This can lead to symptoms such as hot flashes, mood swings, and vaginal dryness. By providing an external source of these hormones, EV/TE can help to alleviate these symptoms.

In addition to its use in menopausal hormone therapy, EV/TE is also used to suppress lactation in postpartum women. This can be beneficial in situations where breastfeeding is not desired or possible.

Related Terms

• Estrogen: A group of hormones that play an essential role in the growth and development of female sexual characteristics and the reproductive process.
• Testosterone: A hormone that plays a key role in the development of male reproductive tissues and promotes secondary sexual characteristics.
• Menopause: A natural biological process, typically occurring in women in their late 40s or early 50s, characterized by the cessation of menstruation and the ability to conceive.
• Postpartum period: The period immediately after the birth of a child, during which the mother's body, including hormone levels and uterus size, returns to a non-pregnant state.

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