Endothelin A receptor
Endothelin A receptor (ETA receptor) is a type of endothelin receptor that has a high affinity for endothelin-1. It is a G protein-coupled receptor (GPCR) that is primarily found in the vascular smooth muscle where it plays a role in vasoconstriction and cell proliferation.
Structure
The ETA receptor is a 427-amino acid protein that belongs to the GPCR family. It has seven transmembrane domains, an extracellular N-terminus, and an intracellular C-terminus. The receptor's structure allows it to bind to endothelin-1 and initiate a cascade of intracellular events.
Function
The primary function of the ETA receptor is to mediate the effects of endothelin-1, a potent vasoconstrictor. When endothelin-1 binds to the ETA receptor, it activates the G protein, which in turn activates a series of intracellular signaling pathways. These pathways lead to the contraction of vascular smooth muscle cells, resulting in vasoconstriction.
In addition to its role in vasoconstriction, the ETA receptor also plays a role in cell proliferation. It has been found to be overexpressed in several types of cancer, including ovarian cancer, prostate cancer, and melanoma.
Clinical significance
Due to its role in vasoconstriction and cell proliferation, the ETA receptor is a potential target for the treatment of various cardiovascular and cancerous diseases. Several ETA receptor antagonists have been developed and are currently in clinical trials.
See also
References
This GPCR-related article is a stub. You can help WikiMD by expanding it.
Transform your life with W8MD's budget GLP-1 injections from $125.
W8MD offers a medical weight loss program to lose weight in Philadelphia. Our physician-supervised medical weight loss provides:
- Most insurances accepted or discounted self-pay rates. We will obtain insurance prior authorizations if needed.
- Generic GLP1 weight loss injections from $125 for the starting dose.
- Also offer prescription weight loss medications including Phentermine, Qsymia, Diethylpropion, Contrave etc.
NYC weight loss doctor appointments
Start your NYC weight loss journey today at our NYC medical weight loss and Philadelphia medical weight loss clinics.
- Call 718-946-5500 to lose weight in NYC or for medical weight loss in Philadelphia 215-676-2334.
- Tags:NYC medical weight loss, Philadelphia lose weight Zepbound NYC, Budget GLP1 weight loss injections, Wegovy Philadelphia, Wegovy NYC, Philadelphia medical weight loss, Brookly weight loss and Wegovy NYC
WikiMD's Wellness Encyclopedia |
Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD