E2F2

E2F2 is a protein that in humans is encoded by the E2F2 gene. The protein is a member of the E2F family of transcription factors, which play a crucial role in controlling the cell cycle and the action of tumor suppressor proteins. E2F2 is also believed to be a target of the transforming proteins of small DNA tumor viruses.

Function

The E2F2 protein is a transcriptional activator that binds to DNA and regulates the expression of various genes involved in the cell cycle. It is particularly important in the G1/S transition, where it helps to control the progression of the cell cycle from the G1 phase to the S phase. E2F2 also plays a role in apoptosis, or programmed cell death, and is thought to be involved in the development of various types of cancer.

Structure

E2F2 is a 437-amino acid protein that contains a DNA-binding domain and a dimerization domain, which allows it to form complexes with other proteins. The DNA-binding domain is responsible for recognizing and binding to specific DNA sequences, while the dimerization domain allows E2F2 to interact with other proteins, such as DP1 and DP2, to form active transcriptional complexes.

Clinical Significance

Alterations in the function of E2F2 have been implicated in a variety of cancers, including breast cancer, lung cancer, and prostate cancer. Overexpression of E2F2 has been observed in these cancers, suggesting that it may play a role in their development. In addition, E2F2 has been identified as a potential therapeutic target for cancer treatment.

See Also

• E2F
• Cell cycle
• Transcription factor
• Cancer

References

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