Dose-response
Dose-response Relationship
The Dose-response relationship (pronounced: dohs-rih-spons ri-lay-shun-ship) is a fundamental concept in Pharmacology and Toxicology, describing the change in effect on an organism caused by differing levels of exposure (or doses) to a stressor (usually a chemical) after a certain exposure time.
Etymology
The term "Dose-response relationship" is derived from the fields of Pharmacology and Toxicology. "Dose" refers to the quantity of a substance that may be absorbed by a living organism, while "response" refers to the reaction or effect elicited by the organism due to the dose.
Definition
A Dose-response relationship is characterized by the alterations in the biological state of an organism that result from exposure to a substance. This relationship is used to examine the effects of various doses of drugs or chemicals on living organisms. The relationship is typically analyzed using dose-response curves and models, which are mathematical representations of the relationship.
Related Terms
- Pharmacodynamics: The study of the biochemical and physiological effects of drugs and their mechanisms of action.
- Pharmacokinetics: The study of how an organism affects a drug, including absorption, distribution, metabolism, and excretion.
- Toxicity: The degree to which a substance can harm humans or animals.
- Threshold dose: The dose below which no effect is observed and above which effects become increasingly apparent.
- LD50: The dose of a substance that is lethal to 50% of a test population.
See Also
External links
- Medical encyclopedia article on Dose-response
- Wikipedia's article - Dose-response
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