Digenea
A class of parasitic flatworms
Digenea is a subclass of Trematoda, commonly known as flukes, which are parasitic flatworms. These organisms are of significant medical and veterinary importance due to their role as parasites in humans and other animals. Digeneans have complex life cycles involving multiple hosts, typically including a mollusk as the first intermediate host and a vertebrate as the definitive host.
Morphology
Digeneans are characterized by their flattened, leaf-like bodies. They possess two suckers: an oral sucker surrounding the mouth and a ventral sucker, or acetabulum, used for attachment to the host. The body is covered by a tegument, which is a specialized outer layer that protects the parasite from the host's immune system.
Life Cycle
The life cycle of digeneans is complex and involves several stages:
- Eggs: The life cycle begins with eggs being released into the environment, often through the feces of the definitive host.
 - Miracidium: The eggs hatch into free-swimming larvae called miracidia, which must find and penetrate a suitable molluscan host.
 - Sporocyst and Redia: Inside the mollusk, the miracidium transforms into a sporocyst, which then produces rediae. These stages multiply asexually.
 - Cercaria: Rediae give rise to cercariae, which are free-swimming larvae that leave the mollusk to find a second intermediate host or directly infect the definitive host.
 - Metacercaria: In some species, cercariae encyst as metacercariae in a second intermediate host or on vegetation.
 - Adult Fluke: The definitive host becomes infected by ingesting metacercariae, where they develop into adult flukes in the host's organs.
 
Pathogenicity
Digeneans can cause significant disease in their hosts. For example, the liver fluke Fasciola hepatica causes fascioliasis, a disease that affects the liver and bile ducts of humans and livestock. Symptoms in humans can include abdominal pain, fever, and jaundice.
Examples of Digeneans
- Schistosoma species, which cause schistosomiasis, a major human disease.
 - Clonorchis sinensis, the Chinese liver fluke, which causes clonorchiasis.
 - Paragonimus westermani, the lung fluke, which causes paragonimiasis.
 
Prevention and Control
Controlling digenean infections involves breaking the life cycle of the parasite. This can be achieved through:
- Improved sanitation to prevent contamination of water sources with eggs.
 - Control of intermediate hosts, such as snails, through environmental management or molluscicides.
 - Public health education to reduce exposure to contaminated water or food.
 
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Contributors: Prab R. Tumpati, MD