Desmethylsertraline
Desmethylsertraline is a pharmacological compound that is the primary metabolite of the antidepressant medication sertraline. It is produced in the body during the metabolic breakdown of sertraline, and has been studied for its potential effects on mood and mental health.
Pharmacology
Desmethylsertraline is produced in the body through the process of N-demethylation, in which a methyl group is removed from the sertraline molecule. This process is primarily carried out by the enzymes CYP2C19 and CYP2B6 in the liver.
The pharmacological activity of desmethylsertraline is not fully understood. It is known to be less potent than sertraline in inhibiting the reuptake of serotonin, a neurotransmitter that is involved in mood regulation. However, it is also less selective, meaning it may affect the reuptake of other neurotransmitters as well.
Clinical Significance
The clinical significance of desmethylsertraline is not yet fully understood. Some studies have suggested that it may contribute to the therapeutic effects of sertraline, while others have suggested that it may be associated with side effects. Further research is needed to fully understand the role of this metabolite in the treatment of depression and other mental health conditions.
Research
Research into desmethylsertraline is ongoing. Some studies have suggested that the levels of this metabolite in the body may be a useful marker for the effectiveness of sertraline treatment. Other research has focused on the potential for desmethylsertraline to be developed as a standalone treatment for depression or other mental health conditions.
See Also
Desmethylsertraline skeletal structure
Desmethylsertraline molecule ball-and-stick model
Transform your life with W8MD's budget GLP-1 injections from $125.
W8MD offers a medical weight loss program to lose weight in Philadelphia. Our physician-supervised medical weight loss provides:
- Most insurances accepted or discounted self-pay rates. We will obtain insurance prior authorizations if needed.
- Generic GLP1 weight loss injections from $125 for the starting dose.
- Also offer prescription weight loss medications including Phentermine, Qsymia, Diethylpropion, Contrave etc.
NYC weight loss doctor appointments
Start your NYC weight loss journey today at our NYC medical weight loss and Philadelphia medical weight loss clinics.
- Call 718-946-5500 to lose weight in NYC or for medical weight loss in Philadelphia 215-676-2334.
- Tags:NYC medical weight loss, Philadelphia lose weight Zepbound NYC, Budget GLP1 weight loss injections, Wegovy Philadelphia, Wegovy NYC, Philadelphia medical weight loss, Brookly weight loss and Wegovy NYC
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
