Dermatopathia pigmentosa reticularis
Dermatopathia Pigmentosa Reticularis (pronunciation: der-ma-to-path-ia pig-men-tosa re-tic-u-laris) is a rare, genetic skin disorder characterized by hyperpigmentation, noncicatricial alopecia, and nail dystrophy. It is a form of Ectodermal Dysplasia.
Etymology
The term Dermatopathia Pigmentosa Reticularis originates from the Greek words derma meaning skin, pathos meaning disease, pigmentosa referring to pigmentation, and reticularis indicating the reticular or net-like pattern of the skin changes observed in this condition.
Symptoms
The primary symptoms of Dermatopathia Pigmentosa Reticularis include Hyperpigmentation, Noncicatricial Alopecia, and Nail Dystrophy. Hyperpigmentation refers to the darkening of the skin, while noncicatricial alopecia refers to hair loss that does not lead to scarring. Nail dystrophy refers to any deformity or disease related to the nails.
Causes
Dermatopathia Pigmentosa Reticularis is caused by mutations in the KRT14 gene. This gene provides instructions for making a protein that is a crucial component of Keratinocytes, the cells that make up most of the skin's outer layer.
Diagnosis
Diagnosis of Dermatopathia Pigmentosa Reticularis is based on clinical examination, patient history, and confirmed by genetic testing of the KRT14 gene.
Treatment
There is currently no cure for Dermatopathia Pigmentosa Reticularis. Treatment is symptomatic and supportive, focusing on managing the individual symptoms and complications of the disorder.
See Also
External links
- Medical encyclopedia article on Dermatopathia pigmentosa reticularis
- Wikipedia's article - Dermatopathia pigmentosa reticularis
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