DDIT4L

Ideogram human chromosome 4

== DDIT4L ==

DDIT4L is a protein-coding gene that plays a crucial role in various cellular processes. It is located on chromosome 5 in humans and is highly conserved across different species. The DDIT4L gene encodes a protein that is involved in the regulation of cell growth, proliferation, and survival.

Function

The DDIT4L protein functions as a negative regulator of the mTOR signaling pathway, which is a key pathway involved in cell growth and metabolism. By inhibiting mTOR activity, DDIT4L helps to control cell growth and prevent excessive proliferation. Additionally, DDIT4L has been implicated in the response to cellular stress and is involved in the regulation of autophagy, a process that helps to maintain cellular homeostasis.

Clinical Significance

Mutations in the DDIT4L gene have been associated with various diseases, including cancer and metabolic disorders. Dysregulation of the mTOR pathway, due to alterations in DDIT4L expression, can lead to uncontrolled cell growth and contribute to the development of cancer. Understanding the role of DDIT4L in disease pathogenesis may provide insights into potential therapeutic strategies for targeting the mTOR pathway in cancer treatment.

References

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