Corticobasal degeneration
Corticobasal Degeneration (kor-ti-ko-ba-sal de-gen-er-a-tion) is a rare, progressive neurodegenerative disease that affects the cortex and basal ganglia of the brain.
Etymology
The term "Corticobasal Degeneration" is derived from the areas of the brain that are primarily affected by the disease: the cerebral cortex and the basal ganglia. "Degeneration" refers to the progressive deterioration of these areas.
Definition
Corticobasal Degeneration (CBD) is a type of Parkinsonism characterized by a combination of motor, cognitive, and behavioral symptoms. It is caused by the degeneration of multiple areas of the brain, including the frontal and parietal lobes and the basal ganglia. The disease is often associated with abnormal protein deposits known as tau proteins.
Symptoms
The symptoms of Corticobasal Degeneration can vary widely among individuals but often include:
- Rigidity and akinesia (lack of movement)
- Myoclonus (involuntary muscle jerks)
- Dystonia (abnormal muscle postures)
- Apraxia (difficulty performing purposeful movements)
- Aphasia (language difficulties)
- Alien limb phenomenon (involuntary movements of a limb)
- Cognitive and behavioral changes
Diagnosis
Diagnosis of Corticobasal Degeneration is primarily based on clinical examination and the presence of characteristic symptoms. Neuroimaging techniques such as MRI and PET scan can be used to support the diagnosis. However, definitive diagnosis can only be confirmed through post-mortem examination of the brain.
Treatment
There is currently no cure for Corticobasal Degeneration. Treatment is symptomatic and may include medications to manage motor symptoms, physical and occupational therapy, and speech therapy for language difficulties.
Prognosis
Corticobasal Degeneration is a progressive disease, with symptoms typically worsening over time. The rate of progression can vary widely among individuals.
See Also
External links
- Medical encyclopedia article on Corticobasal degeneration
- Wikipedia's article - Corticobasal degeneration
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