Complement c3
Complement C3
Complement C3 (pronounced: /ˈkɒmplɪmɛnt siː θriː/) is a protein of the immune system that plays a central role in the complement system and contributes to innate immunity. As a part of the immune system, Complement C3 is involved in the activation of the complement cascade, which leads to the destruction of foreign cells and pathogens.
Etymology
The term "Complement" comes from the activity of this system in aiding, or "complementing", the immune response. The "C3" designation is derived from the order of discovery of the complement components, with C3 being the third component discovered.
Function
Complement C3 is a key protein in the complement system, acting as a central component in both the classical and alternative pathways. It is cleaved into two fragments, C3a and C3b, upon activation. C3b can bind to the surface of pathogens, marking them for destruction by phagocytes, while C3a acts as a chemotactic agent, attracting immune cells to the site of infection.
Related Terms
- Complement system: The system of proteins that Complement C3 is a part of.
- Complement cascade: The sequence of reactions that leads to the activation of the complement system.
- Phagocytes: Cells that can engulf and destroy pathogens.
- Chemotactic agent: A substance that attracts immune cells to a specific location.
See Also
External links
- Medical encyclopedia article on Complement c3
- Wikipedia's article - Complement c3
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