Chondroitinase treatment
Chondroitinase Treatment
Chondroitinase treatment (pronunciation: kon-droi-tin-ase) is a therapeutic approach that involves the use of the enzyme Chondroitinase ABC to degrade chondroitin sulfate proteoglycans (CSPGs) in the extracellular matrix (ECM) of the central nervous system (CNS). This treatment is primarily used in the field of neuroscience to promote neural regeneration after injury.
Etymology
The term "Chondroitinase" is derived from "chondroitin", a type of glycosaminoglycan found in the ECM, and "-ase", a suffix used in biochemistry to denote enzymes. The term "treatment" comes from the Latin "tractare", meaning to handle, manage, or deal with.
Mechanism of Action
Chondroitinase ABC works by cleaving the glycosidic bonds of CSPGs, thereby modifying the ECM and creating a more permissive environment for neural regeneration. This is particularly important in the CNS, where CSPGs are known to inhibit axon growth and plasticity.
Clinical Applications
Chondroitinase treatment has been studied in various neurological disorders, including spinal cord injury, stroke, and multiple sclerosis. In these conditions, the degradation of CSPGs can help to promote neural regeneration and improve functional recovery.
Related Terms
- Chondroitinase ABC
- Chondroitin sulfate proteoglycans
- Extracellular matrix
- Central nervous system
- Neural regeneration
- Axon growth
- Plasticity
- Neurological disorders
- Spinal cord injury
- Stroke
- Multiple sclerosis
External links
- Medical encyclopedia article on Chondroitinase treatment
- Wikipedia's article - Chondroitinase treatment
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