Cd33
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Cd33 (pronounced as C-D-Three-Three), also known as SIGLEC3 or Sialic acid-binding Ig-like lectin 3, is a protein that in humans is encoded by the CD33 gene.
Etymology
The term Cd33 is derived from the abbreviation of Cluster of Differentiation 33, a classification system for cell surface molecules present on white blood cells.
Function
Cd33 is a transmembrane receptor expressed on cells of myeloid lineage. It is usually considered myeloid-specific, but it can also be found on some lymphoid cells.
Clinical Significance
In clinical medicine, Cd33 is significant due to its role in various diseases. It is a therapeutic target in acute myeloid leukemia (AML), where it is expressed in over 90% of cases.
Related Terms
- Acute Myeloid Leukemia: A type of cancer of the blood and bone marrow with excess immature white blood cells.
- Myeloid lineage: A group of cells that develop into the red blood cells, platelets, and most types of white blood cells.
- Transmembrane receptor: A type of protein that spans the cell membrane and transmits signals from outside the cell to inside.
See Also
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