Cd28

CD28

CD28 (pronounced "C-D twenty-eight") is a protein that in humans is encoded by the CD28 gene. It is a type of molecule known as a co-stimulatory molecule, which plays a crucial role in regulating T cell responses.

Etymology

The term "CD28" stands for "Cluster of Differentiation 28". The Cluster of Differentiation is a protocol used for the identification and investigation of cell surface molecules present on leukocytes. CD28 was the 28th cluster of differentiation identified.

Function

CD28 is expressed on T cells and provides the co-stimulatory signal required for T cell activation. This signal is provided by antigen-presenting cells (APCs) and leads to the production of interleukin-2 (IL-2), which promotes T cell proliferation and survival.

Related Terms

• T cell: A type of white blood cell that is of key importance to the immune system and is at the core of adaptive immunity.
• Antigen-presenting cell (APC): A type of immune cell that captures, processes, and presents antigens to T-cells.
• Interleukin-2 (IL-2): A type of cytokine signaling molecule in the immune system. It is a protein that regulates the activities of white blood cells that are responsible for immunity.
• Co-stimulatory molecule: Molecules that provide signals resulting in T cell activation.
• Cluster of Differentiation: A protocol used for the identification and investigation of cell surface molecules present on leukocytes.

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