CETP inhibitor

CETP inhibitor is a type of drug that inhibits the action of cholesteryl ester transfer protein (CETP). CETP is a plasma protein that facilitates the transport of cholesteryl esters and triglycerides between the lipoproteins. By inhibiting CETP, these drugs raise high-density lipoprotein (HDL) cholesterol and reduce low-density lipoprotein (LDL) cholesterol in the blood.

Mechanism of Action

CETP inhibitors work by blocking the action of CETP. This protein normally transfers cholesteryl esters from HDL cholesterol to LDL cholesterol and very low-density lipoprotein (VLDL). By inhibiting CETP, these drugs increase the levels of HDL cholesterol and decrease the levels of LDL cholesterol in the blood.

Uses

CETP inhibitors are used in the treatment of hypercholesterolemia, a condition characterized by high levels of cholesterol in the blood. They are also being investigated for their potential to reduce the risk of cardiovascular disease.

Examples

Examples of CETP inhibitors include Anacetrapib, Dalcetrapib, Evacetrapib, and Torcetrapib. However, some of these drugs have been associated with adverse effects, and their use is currently limited.

Side Effects

Potential side effects of CETP inhibitors include hypertension, dyspnea, edema, and gastrointestinal disorders. Some CETP inhibitors have also been associated with an increased risk of cardiovascular events.

See Also

• Cholesterol
• Lipoprotein
• Cardiovascular disease
• Hypercholesterolemia

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  Torcetrapib chemical structure