CCDC177

CCDC177

CCDC177 is a gene that encodes a protein known as Coiled-Coil Domain Containing 177. This protein is part of a family of proteins characterized by the presence of coiled-coil domains, which are structural motifs involved in protein-protein interactions. The specific function of CCDC177 in human biology is not fully understood, but it is believed to play a role in cellular processes due to its structural properties.

Gene and Protein Structure

The CCDC177 gene is located on chromosome 2 in humans. It spans several kilobases and consists of multiple exons that are transcribed into mRNA. The mRNA is then translated into the CCDC177 protein, which contains coiled-coil domains. These domains are known for facilitating the formation of protein complexes by enabling the protein to interact with other proteins.

Coiled-Coil Domains

Coiled-coil domains are structural motifs in proteins where 2-7 alpha-helices are coiled together like the strands of a rope. These domains are involved in a variety of cellular functions, including the formation of the cytoskeleton, regulation of gene expression, and intracellular transport. The presence of these domains in CCDC177 suggests that it may be involved in similar cellular processes.

Function

While the precise biological function of CCDC177 is not well characterized, proteins with coiled-coil domains are often involved in important cellular functions such as:

• Structural Support: Coiled-coil proteins can form fibrous structures that provide mechanical support to cells.
• Signal Transduction: They can participate in signaling pathways by acting as scaffolds that bring together different signaling molecules.
• Intracellular Transport: Coiled-coil proteins can be involved in the transport of molecules within the cell.

Clinical Significance

Currently, there is limited information on the clinical significance of CCDC177. However, like many genes encoding coiled-coil domain proteins, mutations or dysregulation of CCDC177 could potentially be implicated in various diseases. Further research is needed to elucidate its role in health and disease.

Research Directions

Ongoing research aims to better understand the function of CCDC177 and its interactions with other proteins. Studies may focus on:

• Protein Interactions: Identifying binding partners of CCDC177 to determine its role in cellular pathways.
• Gene Expression: Investigating the regulation of CCDC177 expression in different tissues and under various physiological conditions.
• Disease Association: Exploring potential links between CCDC177 and specific diseases, particularly those involving structural proteins or signaling pathways.

See Also

• Coiled-Coil Domain
• Protein-Protein Interactions
• Chromosome 2 (Human)

External Links

• [NCBI Gene Database: CCDC177](https://www.ncbi.nlm.nih.gov/gene/)
• [UniProt: CCDC177](https://www.uniprot.org/uniprot/)

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Template:Molecular and Cell Biology

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  CCDC177 gene

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  CCDC177 Tertiary Structure

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  CCDC177 NCBI Geo Profile GDS596

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  PTM figure

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  Conceptual Translation

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  MYA Graph

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  CCDC177 Unrooted Evolutionary Tree